Amyotrophic Lateral Sclerosis (ALS), widely known as Lou Gehrig’s disease, is a devastating neurodegenerative condition that progressively destroys motor neurons in the brain and spinal cord, leading to muscle weakness and atrophy. In this video, we go inside the Center for Motor Neuron Disease (CMND) at the University of Chicago Medicine, where researchers are making significant strides toward finding potential therapeutic targets and cures.
Led by Dr. Raymond Roos and Dr. Paschalis Kratsios, the CMND team uses a multifaceted approach across three unique model systems: the nematode C. elegans (utilizing its 302 neurons to decode genetic mechanisms), mice, and human motor neurons derived directly from stem cells.
Discover how their critical research into the mutation of the C9ORF72 gene is unlocking new pathways for inherited ALS treatments, combining cutting-edge clinical trials with hope for the future.
